病因

Induction of apoptosis by Etoposide was associated with up-regulation of mRNAs for the BH3 only proteins Noxa,and to a lesser extent,Bim. BH3-only蛋白Noxa的mRNA表达明显上调,Bim少量上调与依托泊苷诱导的细胞凋亡有关系;

Objective To study the expression level and significance of BH3-only protein Bim, Noxa, Puma in apoptosis of paclitaxel-induced gastric adenocarcinoma cells. 目的研究BH3only蛋白Bim、Noxa、Puma在紫杉醇诱导胃腺癌细胞凋亡中的表达水平及其意义。

Induction of apoptosis of gastric adenocarcinoma calls by Etoposide may be assocaited with up-regulation of the BH3 only proteins of the bcl-2 family,Noxa and Bim. 依托泊苷诱导的胃腺癌细胞凋亡与BH3-only蛋白Noxa和Bim表达上调有关联。