n.[化]亲核试剂

Amines can engage in nucleophile substitution reaction with alky. 胺能参加与卤代烷的亲核取代反应。

For a nucleophile, its regioselectivity is also controlled by both steric hindrance and electronic effect. 对于亲核试剂，一般的亲核试剂也同时受电子效应和空间效应的影响；

The target tripeptide was synthesized in ethanol/ This-HCl buffer system with Bz-Arg-OEt as acyl donor and Gly-Asp-(NH2)2 as the nucleophile. 然后以Bz-Arg-OEt为酰基供体，以Gly-Asp-(NH2)2为亲核试剂，在乙醇/Tris-HCI反应体系中，用胰蛋白酶作催化剂催化合成了目标三肽。在试验中我们发现经过pH处理过的胰蛋白酶与酶粉作为催化剂相比具有的催化活力更高，产物产率好的优点。

The kinetic data indicated that the mono-deprotonated oxime group could act as an effective intramolecular nucleophile in the reaction. 实验结果表明，单去质子化的肟基可以作为反应过程中的分子内亲核剂。

Catalyzed by sulfuric acid, 2 and 5 were converted to the same product (such as 3c) 3 (or 4) when mercaptan (or phenyl-sulfohydrate) was used as the nucleophile. 所得加成产物在酸催化条件下以乙硫醇为亲核体时生成芳基乙基硫醚;